Publications
2024
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets
John M Bennett, Sunil K Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L Li, Ryan K Muir, Franco F Faucher, Scott Lovell, Michael J Blackman, Alexander Adibekian, Ellen Yeh, David A Fidock, Matthew Bogyo
bioRxiv: 10.1101/2024.01.11.575224
2023
Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections
Edward JA Douglas, Sri W Wulandari, Scott D Lovell, Maisem Laabei
Microbial biotechnology: 10.1111/1751-7915.14268
Solid phase synthesis of fluorosulfate containing macrocycles for chemoproteomic workflows
Franco F Faucher, Daniel Abegg, Phillip Ipock, Alexander Adibekian, Scott Lovell, Matthew Bogyo
Israel Journal of Chemistry: 10.1002/ijch.202300020
2022
A KLK6 activity-based probe reveals a role for KLK6 activity in pancreatic cancer cell invasion
Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjær, Annabel Borg, Janosch Hennig, Aubry K Miller, Edward W Tate
Journal of the American Chemical Society: 10.1021/jacs.2c07378
2021
Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
Thomas Kryza*, Tashbib Khan*, Scott Lovell*, Brittney S Harrington, Julia Yin, Sean Porazinski, Marina Pajic, Hannu Koistinen, Juha K Rantala, Tobias Dreyer, Viktor Magdolen, Ute Reuning, Yaowu He, Edward W Tate, John D Hooper
Nature Chemical Biology: 10.1038/s41589-021-00783-w
A suite of activity-based probes to dissect the KLK activome in drug-resistant prostate cancer
Scott Lovell, Leran Zhang, Thomas Kryza, Anna Neodo, Nathalie Bock, Elena De Vita, Elizabeth D Williams, Elisabeth Engelsberger, Congyi Xu, Alexander T Bakker, Maria Maneiro, Reiko J Tanaka, Charlotte L Bevan, Judith A Clements, Edward W Tate
Journal of the American Chemical Society: 10.1021/jacs.1c03950
Identification of highly selective covalent inhibitors by phage display
Shiyu Chen, Scott Lovell, Sumin Lee, Matthias Fellner, Peter D Mace, Matthew Bogyo
Nature Biotechnology: 10.1038/s41587-020-0733-7
Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19
Kas Steuten, Heeyoung Kim, John C Widen, Brett M Babin, Ouma Onguka, Scott Lovell, Oguz Bolgi, Berati Cerikan, Christopher J Neufeldt, Mirko Cortese, Ryan K Muir, John M Bennett, Ruth Geiss-Friedlander, Christoph Peters, Ralf Bartenschlager, Matthew Bogyo
ACS Infectious Diseases: 10.1021/acsinfecdis.0c00815
2020
Strategies for tuning the selectivity of chemical probes that target serine hydrolases
Franco Faucher, John M Bennett, Matthew Bogyo, Scott Lovell
Cell Chemical Biology: 10.1016/j.chembiol.2020.07.008
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
Bruno M Simões, Angélica Santiago-Gómez, Chiara Chiodo, Tiago Moreira, Daniel Conole, Scott Lovell, Denis Alferez, Rachel Eyre, Katherine Spence, Aida Sarmiento-Castro, Bertram Kohler, Ludivine Morisset, Marilena Lanzino, Sebastiano Andò, Elisabetta Marangoni, Andrew H Sims, Edward W Tate, Sacha J Howell, Robert B Clarke
Oncogene: 10.1038/s41388-020-1335-z
Faecal neutrophil elastase-antiprotease balance reflects colitis severity
Rachael Barry, David Ruano-Gallego, Shiva T Radhakrishnan, Scott Lovell, Lu Yu, Olga Kotik, Izabela Glegola-Madejska, Edward W Tate, Jyoti S Choudhary, Horace RT Williams, Gad Frankel
Mucosal Immunology: 10.1038/s41385-019-0235-4
The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
Thomas Kryza, Nathalie Bock, Scott Lovell, Anja Rockstroh, Melanie L Lehman, Adam Lesner, Janaththani Panchadsaram, Lakmali Munasinghage Silva, Srilakshmi Srinivasan, Cameron E Snell, Elizabeth D Williams, Ladan Fazli, Martin Gleave, Jyotsna Batra, Colleen Nelson, Edward W Tate, Jonathan Harris, John D Hooper, Judith A Clements
Molecular Oncology: 10.1002/1878-0261.12587
2019
Chemical Probes for Proteins and Networks
Scott Lovell, Charlotte L Sutherell, Edward W Tate
Mass Spectrometry‐Based Chemical Proteomics: 978-1-118-97020-1
2018
Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity
Elena De Vita, Peter Schüler, Scott Lovell, Jasmin Lohbeck, Sven Kullmann, Eitan Rabinovich, Amiram Sananes, Bernd Heßling, Veronique Hamon, Niv Papo, Jochen Hess, Edward W Tate, Nikolas Gunkel, Aubry K Miller
Journal of Medicinal Chemistry: 10.1021/acs.jmedchem.8b01106
2013
Novel and versatile synthesis of disubstituted 1, 2-dihydro-1, 2, 4-triazol-3-ones
Mark A Graham, Paul A Bethel, Jonathan Burgess, Gary Fairley, Steve C Glossop, Ryan DR Greenwood, Clifford D Jones, Scott Lovell, Steve Swallow
Organic Letters: 10.1021/ol402920z